Ultraschallgeführte Strahlenchirurgie

Projektbeschreibung

Die Kompensation von Atembewegungen ist eines der schwierigsten Forschungsgebiete der Strahlentherapie. Für eine zielsichere Behandlung beweglicher Tumore muss deren Position fortlaufend erfasst und der Behandlungsstrahl mit kurzer Latenz auf die Bewegung angepasst werden.

Bislang war es nicht möglich, Weichgewebe im menschlichen Körper mit hinreichender Genauigkeit und Geschwindigkeit abzutasten. Klinisch eingesetzte Verfahren nutzen heutzutage langsame, röntgen- und markerbasierte Verfahren zur Absolutortung von Tumorstrukturen. Zusätzlich werden externe Surrogatsignale verwendet, um abhängig vom Atemzustand des Patienten entweder den Behandlungsstrahl an- und abzuschalten (Gating), oder durch ein Korrelationsmodell die interne Tumorposition zu berechnen und die Strahlenquelle nachzuführen.

Beide Ansätze setzen einen festen Zusammenhang zwischen Surrogatsignal und Tumorposition voraus. Fehler in der Erfassung dieses Zusammenhangs oder die Änderung des Modells über die Zeit führen zu Behandlungsfehlern. Darüber hinaus gibt es Bereiche im menschlichen Körper, die sich nicht mittels korrelationsbasierter Bewegungskompensation behandeln lassen. Besonders in Gebieten mit kardiovaskulärer und respiratorischer Bewegung setzt sich die Tumorbewegung aus einer nichtlinearen Kombination dieser Bewegungsquellen zusammen und die Aufstellung eines Modells ist unmöglich, bzw. würde eine viel zu hohe Anzahl von Messpunkten (Röntgenbildern) erfordern.

Mit der Entwicklung schneller 4D Ultraschallgeräte besteht neuerdings die Möglichkeit, Strukturen des menschlichen Körpers mit ausreichend Weichgewebekontrast mehrmals pro Sekunde zu erfassen. Tumorpositionen können in Ultraschallvolumen lokalisiert und direkt zur Bewegungskompensation genutzt werden.

Forschungsgebiete:

  • Zielverfolgung in Ultraschallvolumen
  • Optimierung der Schallkopfposition
  • Robotisierte Schallkopfpositionierung
  • Ultraschallgeführte Strahlentherapie

Veröffentlichungen

Verantwortlich

Floris Ernst
Haus 64 / Raum 95 +49 451 31015208


Ralf Bruder
Haus 64 / Raum 92 +49 451 31015205


2020

Felix von Haxthausen, Svenja Ipsen, Holger Schwegmann, Ralf Bruder, Floris Ernst and Verónica García-Vázquez, A 3D Slicer module for calibration of spatially tracked 3D ultrasound probes, in: International Journal of Computer Assisted Radiology and Surgery, Munich, pages S14-S16, 2020
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Daniel Wulff, Jannis Hagenah, Svenja Ipsen and Floris Ernst, Learning Local Feature Descriptions in 3D Ultrasound, in: The 20th IEEE International Conference on BioInformatics and BioEngineering, IEEE Computer Society, pages 323-330, 2020
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Wimonsiri Khiosapjaroen, Rendering of ultrasound volumes on augmented reality glasses, Lübeck University of Applied Sciences and Universität zu Lübeck, 2020
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Felix von Haxthausen, Jannis Hagenah, Mark Kaschwich, Markus Kleemann, Verónica García-Vázquez and Floris Ernst, Robotized ultrasound imaging of the peripheral arteries – a phantom study, in: Current Directions in Biomedical Engineering, pages 20200033, De Gruyter, 2020
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Svenja Ipsen, Sven Böttger, Holger Schwegmann and Floris Ernst, Target tracking accuracy and latency with different 4D ultrasound systems – a robotic phantom study (2020), in: Current Directions in Biomedical Engineering, 6:1
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Svenja Ipsen, Sven Böttger, Holger Schwegmann and Floris Ernst, Tracking Performance of 4D Ultrasound Systems with Real-Time Streaming Interfaces - A Robotic Phantom Study, in: Medical Physics, Annual Meeting of the American Association of Physicists in Medicine (AAPM), 2020
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Felix von Haxthausen, Till Aust, Holger Schwegmann, Sven Böttger, Floris Ernst, Verónica García-Vázquez, Markus Kleemann and Mark Kaschwich, Visual servoing for semi-automated 2D ultrasound scanning of peripheral arteries, in: Proc AUTOMED (2020), Infinite Science Publishing GmbH, 2020
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2019

Svenja Ipsen, Ralf Bruder, Verónica García-Vázquez, Achim Schweikard and Floris Ernst, Assessment of 4D Ultrasound Systems for Image-guided Radiation Therapy – Image Quality, Framerates and CT Artifacts, German Society for Biomedical Engineering, 2019
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Sven Böttger, Markus Kleemann and Floris Ernst, Ergebnisse einer Akzeptanzumfrage zur Roboter-assistierten Ultraschalldiagnostik unter Gefäßmedizinern, Deutsche Gesellschaft für Chirurgie, 2019
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Svenja Ipsen, Ivo Kuhlemann, Achim Schweikard and Floris Ernst, MO-K-303-3: Continuous long-term imaging with robotic 4D ultrasound for motion compensation in radiotherapy and beyond, in: Medical Physics, Annual Meeting of the American Association of Physicists in Medicine (AAPM), pages E287-E288, 2019
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Sven Böttger, Felix von Haxthausen, Markus Kleemann, Floris Ernst and Achim Schweikard, Robotics from the bench – Research for ultrasound automation with augmented reality visualization, in: 17th Three-Country Conference Minimally Invasive Surgery MIC 2019, 2019
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Daniel Wulff, Ivo Kuhlemann, Floris Ernst, Achim Schweikard and Svenja Ipsen, Robust motion tracking of deformable targets in the liver using binary feature libraries in 4D ultrasound, German Society for Biomedical Engineering, 2019
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Svenja Ipsen, Floris Ernst, Verónica García-Vázquez and Achim Schweikard, SU-F-303-3: Assessment of CT artefacts caused by matrix array transducers for intra-modality registration in 4D ultrasound-guided radiotherapy, in: Medical Physics, Annual Meeting of the American Association of Physicists in Medicine (AAPM), pages E132-E133, 2019
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2018

Svenja Ipsen, Ralf Bruder, Ivo Kuhlemann, Philipp Jauer, Laura Motisi, Florian Cremers, Floris Ernst and Achim Schweikard, A visual probe positioning tool for 4D ultrasound-guided radiotherapy, IEEE Engineering in Medicine and Biology Society (EMBS), 2018
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Felix von Haxthausen, Floris Ernst, Ralf Bruder and Verónica García-Vázquez, Real-Time Streaming of 3D Ultrasound Data to HoloLens, in: 52nd Annual Conference of the German Society for Biomedical Engineering (BMT 2018), Aachen (Germany), pages S344, 2018
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Sven Böttger, Markus Kleemann, Mohammed Al-Badri, Svenja Ipsen, Ivo Kuhlemann, Ralf Bruder and Floris Ernst, Robotergestützte Ultraschall-Plattform für die Automatisierung und Standardisierung von Screening-Verfahren (2018), in: 135. Kongress der Deutschen Gesellschaft für Chirurgie(161)
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Felix von Haxthausen, Floris Ernst, Ralf Bruder and Verónica García-Vázquez, Streaming of 3D Data from Ultrasound Systems to Augmented Reality Glasses (HoloLens), in: Tagungsgband der 17. Jahrestagung der Deutschen Gesellschaft für Computer- und Roboterassistierte Chirurgie (CURAC), Leipzig (Germany), pages 2-3, Thomas Neumuth, Andreas Melzer, Claire Chalopin, 2018
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Svenja Ipsen, Ralf Bruder, Floris Ernst and Achim Schweikard, WE-HI-KDBRB1-02: Characterization of 4D ultrasound systems with streaming interfaces for real-time motion compensation in radiotherapy, in: Medical Physics, Annual Meeting of the American Association of Physicists in Medicine (AAPM), pages E644, 2018
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Svenja Ipsen, [I094] Ultrasound guidance in radiotherapy - Renaissance through innovation, in: Physica Medica, European Federation of Organisations For Medical Physics (EFOMP), pages 57, Elsevier, 2018
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2017

Ivo Kuhlemann and Floris Ernst, A safety module for active joint limit avoidance and intuitive hand guidance of a robotic ultrasound system, in: International Journal of Computer Assisted Radiology and Surgery, CARS 2017, pages 38-39, Springer, 2017
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Sven Böttger, Svenja Ipsen, Mohammed Al-Badri, Floris Ernst and Achim Schweikard, Force sensitive robotics for automated ultrasonic diagnostics and therapy, Joint conference of the German, Austrian and Swiss Societies for Biomedical Engineering, Dresden, pages s103-s108, De Gruyter, 2017
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Stefan Gerlach, Ivo Kuhlemann, Floris Ernst, Christoph Fürweger and Alexander Schlaefer, Impact of robotic ultrasound image guidance on plan quality in SBRT of the prostate (2017), in: The British Journal of Radiology, 90:1078(20160926)
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Svenja Ipsen, Ralf Bruder, Esben Schjødt Worm, Rune Hansen, Per Rugaard Poulsen, Morten Høyer and Achim Schweikard, MO-DE-708-6: In-vivo comparison of real-time 4D ultrasound tracking with electromagnetic transponders in the liver during free breathing, in: Medical Physics, Annual Meeting fo the American Association of Physicists in Medicine (AAPM), pages 3069, 2017
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Mohammed Al-Badri, Svenja Ipsen, Sven Böttger and Floris Ernst, Robotic 4D ultrasound solution for real-time visualization and teleoperation (2017), in: Current Directions in Biomedical Engineering, 3:2(559-561)
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Svenja Ipsen, Ralf Bruder, Esben Schjødt Worm, Rune Hansen, Per Rugaard Poulsen, Morten Høyer and Achim Schweikard, Simultaneous acquisition of 4D ultrasound and wireless electromagnetic tracking for in-vivo accuracy validation (2017), in: Current Directions in Biomedical Engineering, 3:2(75-78)
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2016

Svenja Ipsen, Ralf Bruder, Philipp Jauer, Floris Ernst, Oliver Blanck and Achim Schweikard, An improved tracking framework for ultrasound probe localization in image-guided radiosurgery (2016), in: Current Directions in Biomedical Engineering, 2:1(409-413)
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Stefan Gerlach, Ivo Kuhlemann, Philipp Jauer, Ralf Bruder, Floris Ernst, Christoph Fürweger and Alexander Schlaefer, Feasibility of robotic ultrasound guided SBRT of the prostate, in: CARS 2016, 30th International Congress and Exhibition, Heidelberg, 2016
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Svenja Ipsen, Ralf Bruder, Rick O'Brian, Paul J. Keall, Achim Schweikard and Per Rugaard Poulsen, Online 4D ultrasound guidance for real-time motion compensation by MLC tracking (2016), in: Medical Physics(5695-5704)
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Svenja Ipsen, Ralf Bruder and Achim Schweikard, P28: Towards 6dof tracking of deformable objects for 4D ultrasound-guided radiation therapy, in: Australasian Physical & Engineering Sciences in Medicine, Sydney, Australia, Springer Netherlands, 2016
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Jeffrey Schlosser, Renhui Gong, Ralf Bruder, Achim Schweikard, Sungjune Jang, John Henrie, Aya Kamaya, Albert Koong, Daniel Chang and Dimitre Hristov, Robotic intra-fractional US guidance for liver SABR: system design, beam avoidance, and clinical imaging (2016), in: Medical Physics(5951-5963)
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Stefan Gerlach, Ivo Kuhlemann, Philipp Jauer, Ralf Bruder, Floris Ernst, Christoph Fürweger and Alexander Schlaefer, Robotic ultrasound-guided SBRT of the prostate: feasibility with respect to plan quality (2016), in: International Journal of Computer Assisted Radiology and Surgery(1--11)
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Svenja Ipsen, Ralf Bruder, Ricky T O'Brien, Paul J. Keall, Achim Schweikard and Per Rugaard Poulsen, TH-AB-202-05: BEST IN PHYSICS (JOINT IMAGING-THERAPY): First Online Ultrasound-Guided MLC Tracking for Real-Time Motion Compensation in Radiotherapy, in: Medical Physics, Annual Meeting of the American Association of Physicists in Medicine (AAPM), pages 3857-3857, 2016
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2015

Ralf Bruder, Floris Ernst, Oliver Blanck, Jürgen Dunst and Achim Schweikard, 4D Ultrasound Image Guidance for Cardiac Radiosurgery, in: International Workshop on Ultrasound Guidance in Radiotherapy, Cookham, UK, 2015
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Dimitre Hristov, Renhui Gong, Jeffrey Schlosser, Ralf Bruder and Achim Schweikard, Augmented reality system for robotic ultrasound guidance of external beam radiation therapy, in: Proceedings of the 29th International Congress and Exhibition on Computer Assisted Radiology and Surgery (CARS'15), Barcelona, Spain, 2015
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Renhui Gong, Ralf Bruder, Achim Schweikard and Dimitre Hristov, Investigation of Treatment Interferences of a Novel Robotic Ultrasound Radiotherapy Guidance System with Clinical VMAT Plans for Liver SBRT Patients (2015), in: Medical Physics(3561)
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Ivo Kuhlemann, Philipp Jauer, Achim Schweikard and Floris Ernst, Patient localization for robotized ultrasound-guided radiation therapy, in: Imaging and Computer Assistance in Radiation Therapy, ICART 2015, 18th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI, pages 105-112, 2015
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Oliver Blanck, Thilo Sothmann, Kenneth Poels, Ralf Bruder, Frank-Andre Siebert, C Grohmann, Dirk Verellen and T Gauer, Tracking-Precision-Comparison of two High-End-Linear Accelerator means 4D-Motion Platform and high resolution Flat Panel Detector, 2015
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2014

Oliver Blanck, F. Bode, Maximilian P. E. Gebhard, P. Hunold, Sebastian Brandt, Ralf Bruder, M. Grossherr, R. Vonthein, Dirk Rades and Jürgen Dunst, Dose-Escalation Study for Cardiac Radiosurgery in a Porcine Model (2014), in: International journal of radiation oncology, biology, physics(89)
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René Werner, F. Bode, Ralf Bruder, M. Gebhard, Jürgen Dunst, Dirk Rades and Oliver Blanck, Impact of cardiac and respiratory motion during cardiac radiosurgery: a dose accumulation study in a porcine model (2014), in: Radiotherapy and Oncology, 111(S197-S198)
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Ivo Kuhlemann, Ralf Bruder, Floris Ernst and Achim Schweikard, WE-G-BRF-09: Force- and Image-Adaptive Strategies for Robotised Placement of 4D Ultrasound Probes, in: 56th Annual Meeting of the AAPM, pages 523, 2014
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2013

Robert Dürichen, Ralf Bruder, Lucas Davenport, Tobias Wissel, Floris Ernst and Achim Schweikard, Correlation and variation of a multi-modal sensor setup for respiratory motion prediction and correlation, in: 55th Annual Meeting & Exhibition of AAPM, American Association of Physicists in Medicine (AAPM), Indianapolis, USA, pages 186, 2013
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Robert Dürichen, Lucas Davenport, Ralf Bruder, Tobias Wissel, Floris Ernst and Achim Schweikard, Evaluation of the potential of multi-modal sensors for respiratory motion prediction and correlation, in: 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 13), Osaka, Japan, pages 5678 - 5681, 2013
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Ralf Bruder, Svenja Ipsen, Philipp Jauer, Floris Ernst, Oliver Blanck and Achim Schweikard, MO-D-144-02: Ultrasound Transducer Localization Using the CyberKnife's X-Ray System, in: 55th Annual Meeting of the AAPM, pages 405, 2013
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Oliver Blanck, Philipp Jauer, Floris Ernst, Ralf Bruder and Achim Schweikard, Pilot-Phantomtest zur ultraschall-geführten robotergestützten Radiochirurgie, in: 44. Jahrestagung der DGMP, DGMP, Cologne, Germany, pages 122-123, 2013
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Oliver Blanck, F. Bode, M. Gebhard, P. Hunold, Stephan A. Brandt, Ralf Bruder, Achim Schweikard, M. Grossherr, Dirk Rades and Jürgen Dunst, Radiosurgery to Create Lesions in the Pulmonary Vein Antrum: Preliminary Results in a Porcine Model and Possible Implications for the Treatment of Atrial Fibrillation, in: The SRS/SBRT Scientific Meeting 2013, 2013
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Ralf Bruder, Gerd Bruder and Achim Schweikard, Verfahren zum Auffinden der Position eines Schallkopfes
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2012

Lars Richter, Ralf Bruder and Achim Schweikard, Calibration of force/torque and acceleration for an independent safety layer in medical robotic systems (2012), in: Cureus, 4:9(e59)
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Lars Richter, Ralf Bruder and Achim Schweikard, Calibration of Force/Torque and Acceleration for an Independent Safety Layer in Medical Robotic Systems (2012), in: Cureus, 4:9(e59)
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Floris Ernst, Ralf Bruder, Alexander Schlaefer and Achim Schweikard, Correlation between external and internal respiratory motion: a validation study (2012), in: International Journal of Computer Assisted Radiology and Surgery, 7:3(483-492)
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Lars Richter, Ralf Bruder and Achim Schweikard, Hand-assisted positioning and contact pressure control for motion compensated robotized transcranial magnetic stimulation, in: Proceedings of the 26th International Congress and Exhibition on Computer Assisted Radiology and Surgery ({CARS}'12), Pisa, Italy, pages 123-124, 2012
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Lars Richter, Ralf Bruder and Achim Schweikard, Hand-assisted positioning and contact pressure control for motion compensated robotized transcranial magnetic stimulation (2012), in: International Journal of Computer Assisted Radiology and Surgery, [Epub ahead of print](1-8)
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Nikolaus Ammann, Robotized 4D Ultrasound for cardiac Image- Guided Radiation Therapy, University of Luebeck, 2012
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2011

Floris Ernst, Ralf Bruder, Alexander Schlaefer and Achim Schweikard, Forecasting Pulsatory Motion for Non-invasive Cardiac Radiosurgery (2011), in: International Journal of Computer Assisted Radiology and Surgery, 6:1(93-101)
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Ralf Bruder, Florian Griese, Floris Ernst and Achim Schweikard, High-accuracy ultrasound target localization for hand-eye calibration between optical tracking systems and three-dimensional ultrasound, in: Bildverarbeitung für die Medizin 2011, pages 179-183, Springer, 2011
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Ralf Bruder, Philipp Jauer, Floris Ernst, Lars Richter and Achim Schweikard, Real-time 4D ultrasound visualization with the Voreen framework, in: ACM SIGGRAPH 2011 Posters, Vancouver, BC, Canada, pages 74:1, ACM, 2011
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Ralf Bruder, Floris Ernst and Achim Schweikard, SU‐D‐220‐02: Optimal transducer positions for 4D ultrasound guidance in cardiac IGRT, in: 53rd Annual Meeting of the AAPM, pages 3390, 2011
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2009

Ralf Bruder, T. Cai, Floris Ernst and Achim Schweikard, 3D ultrasound-guided motion compensation for intravascular radiation therapy, in: Proceedings of the 23rd International Conference and Exhibition on Computer Assisted Radiology and Surgery ({CARS}'09), pages 25--26, 2009
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Svitlana Ens, Ralf Bruder, J. Ulrici, E. Hell and T. M. Buzug, A Validation Framework for Head-Motion Artifacts in Dental Cone-Beam CT, in: Proceedings of the 2009 World Congress on Medical Physics and Biomedical Engineering, pages 658--661, 2009
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Ralf Bruder, Floris Ernst, Alexander Schlaefer and Achim Schweikard, TH-C-304A-07: Real-Time Tracking of the Pulmonary Veins in 3D Ultrasound of the Beating Heart, in: 51st Annual Meeting of the AAPM, pages 2804, 2009
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Ralf Bruder, Ultrasound tracking for motion compensation in radiation therapy, in: Real-Time Motion Adaptive Radiation Therapy Workshop 2009, Institute for Robotics, University of Lübeck, 2009
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