Evaluation of an online navigation system for laparoscopic interventions in a perfused ex vivo artificial tumor model of the liver

Type of publication:  Artikel
Zeitschrift: The Official Journal of the International Hepato Pancreato Biliary Association
Band: 9
Nummer: 3
Jahr: 2007
Seiten: 190--194
Notiz: Navigation in liver surgery
ISSN: 1477-2574
DOI: 10.1080/13651820601089077
Abriss: Background. Laparoscopic radiofrequency ablation (RFA) is a safe and effective method for tumor destruction in patients with unresectable liver tumors. However, accurate probe placement using laparoscopic ultrasound guidance is required to achieve complete tumor ablation. After evaluation of an ultrasound navigation system for transcutaneous and open RFA, we now intend to tranfer this technique to laparoscopic liver surgery. This study aimed to evaluate an electromagnetic navigation system for laparoscopic interventions using a perfusable ex vivo artificial tumor model. Materials and methods. First a special adapter was developed to attach the ultrasound and electromagnetic tracking-based navigation system to a laparoscopic ultrasound probe. The laparoscopic online navigation system was studied in a laparoscopic artificial tumor model using perfused porcine livers. Artificial tumors were created by injection of a mixture of 3% agarose, 3% cellulose, and 7% glycerol, creating hyperechoic lesions in ultrasound. Results. This study showed that laparoscopic ultrasound-guided navigation is technically feasible. Even in cases of angulation of the ultrasound probe no disturbances of the navigation system could be detected. Artificial tumors were clearly visible on laparoscopic ultrasound and not felt during placement of the RFA probe. Anatomic landmarks and simulated 'tumors' in the liver could be reached safely. Discussion. Laparoscopic RFA requires advanced laparoscopic ultrasound skills for accurate placement of the RFA probe. The use of an ultrasound-based, laparoscopic online navigation system offers the possibility of out-of-plane needle placement and could increase the safety and accuracy of punctures. The perfused artificial tumor model presented a realistic model for the evaluation of this new technique.
Schlagworte: artificial tumor model, laparoscopic ultrasound, liver, Navigation, Radiofrequency ablation
Autoren: Hildebrand, Philipp
Martens, Volker
Schweikard, Achim
Schlichting, Stefan
Beširević, Armin
Kleemann, Markus
Roblick, Uwe
Mirow, Lutz
Bürk, Conny
Bruch, Hans-Peter