Modeling of tissue movements and blood flow for valve-preserving reconstruction of the aortic root

Project Description

One possible reason for aortic valve insufficiency is the dilatation of the aortic root. In this case, the aortic root is enlarged but the leaflet shape remains unchanged. This dilatation causes the valve diameter to increase so that the leaflets cannot adjoin each other anymore. Hence, the change of the valve geometry induces an insufficiency. For patients with such a diagnosis, aortic valve reconstruction presents an alternative to valve replacement. The shape of the dilated root is remodeled by attaching the patient's native leaflets to a prosthesis.

In this project we develop models of the aortic root based on patient-specific geometric features taken from transesophageal (TEE) ultrasound images of the heart. Furthermore, these model will be incorporated into an interactive planning tool, which will allow the surgeon to find the optimal prosthesis for the patient at hand.



Jannis Hagenah, Michael Scharfschwerdt, Christoph Metzner, Alexander Schlaefer, H. H. Sievers, and Achim Schweikard,
An approach for patient specific modeling of the aortic valve leaflets, GRIN Verlag, 2014.
Oliver Blanck, Svenja Ipsen, Brad Oborn, Ralf Bruder, René Werner, F. Bode, P. Hunold, Gary Liney, Dirk Rades, Jürgen Dunst, Achim Schweikard, and Paul J. Keall,
Treatment planning for cardiac radiosurgery -- initial human simulations, Zürich, Switzerland , 2014.


Jannis Hagenah, Michael Scharfschwerdt, Birgit Stender, Sven Ott, R. Friedl, H. H. Sievers, and Alexander Schlaefer,
A setup for ultrasound based assessment of the aortic root geometry, 2013.
Bo Wang, Birgit Stender, T. Long, Z. Zhang, and Alexander Schlaefer,
An approach to validate ultrasound surface segmentation of the heart, 2013.
Jannis Hagenah,
"Erstellung eines patientenindividuellen Modells der Aortenklappe" 2013.
Birgit Stender, Floris Ernst, Bo Wang, Z. X. Zhang, and Alexander Schlaefer,
Motion compensation of optical mapping signals from isolated beating rat hearts, San Diego, CA: SPIE, 2013. pp. 88561C-1 - 88561C-6.
File: 12.2024847


Birgit Stender, Bo Wang, and Alexander Schlaefer,
Computing Synthetic Echocardiography Volumes for Automatic Validation of 3D Segmentation Results, 2012.


Birgit Stender, Michael Scharfschwerdt, Floris Ernst, Ralf Bruder, Hamid Hadjar, and Alexander Schlaefer,
Optical Imaging of Cardiac Function: System setup and calibration, Berlin, Germany , 2011. pp. S42-S43.