Transcranial Magnetic Stimulation (TMS)

Project Description

Robot Based TMS Treatment
Robot Based TMS Treatment

Aim of the project is to develop a robot assistance system for delivering TMS. Furthermore, we work on a statistical brain mapping procedure to localise muscle representations in the cortex.

The advantages of robotised TMS are manifold:

  • Precise targeting of stimulation points.
  • Precise tangential orientation of the stimulation coil.
  • Simple planning and fast probing of grid-like stimulation patterns.
  • Motion compensation keeps coil in place even if the patient moves. A fixation of the head is not necessary any more.
  • Repeatability.

For the brain mapping algorithm we combine all three essential pieces of information: The coil positions for stimulation, the corresponding muscle responses, and the characteristic field of the coil used. The main idea is to assume a monotonic functional relation between the electric field strength at the representation point and the evoked muscle response. Using a refined algorithm for Correlation Ratio and Kendall's rank coefficient TAU, we are able to calculate likelihood maps for the representation of specific muscles.

Stimulated Areas of the Brain
Stimulated Areas of the Brain

Publications

2010

Sven Kantelhardt, Tommaso Fadini, Markus Finke, K. Kallenberg, J. Siemerkus, V. Bockermann, Lars Matthäus, Walter Paulus, Achim Schweikard, V. Rohde, and Alf Giese,
Robot-assisted image-guided transcranial magnetic stimulation for somatotopic mapping of the motor cortex: a clinical pilot study, Acta Neurochirurgica , vol. 152, no. 2, pp. 333-343, 2010.
DOI:10.1007/s00701-009-0565-1
File: s00701-009-0565-1

2009

Sven Kantelhardt, Tommaso Fadini, Markus Finke, K. Kallenberg, V. Bockermann, Lars Matthäus, J. Siemerkus, Walter Paulus, Achim Schweikard, V. Rohde, and Alf Giese,
Robotized image-guided transcranial magnetic stimulation, a novel technique for functional brain-mapping, Clinical Neurophysiology , vol. 120, no. 1, pp. e84, 2009.
DOI:10.1016/j.clinph.2008.07.203
File: j.clinph.2008.07.203
Lars Richter, Lars Matthäus, Peter Trillenberg, Claudia Diekmann, Dirk Rasche, and Achim Schweikard,
Behandlung von chronischem Tinnitus mit roboterunterstützter TMS, Lübeck: GI, 2009. pp. 86;1018-1027.
Kristian Ehlers,
Anwendung der FaceAPI zur Bewegungskompensation für die robotergestützte Transkranielle Magnetstimulation, 2009.

2008

Markus Finke, Tommaso Fadini, Sven Kantelhardt, Alf Giese, Lars Matthäus, and Achim Schweikard,
Brain-Mapping using robotized TMS, Vancouver, British Columbia, Canada , 2008. pp. 3929-3932.
Sven Kantelhardt, Tommaso Fadini, K. Kallenberg, Markus Finke, Lars Matthäus, Achim Schweikard, V. Rohde, and Alf Giese,
Comparison of functional brain mapping by computer controled roboterized transcranial-magnet-stimulation and functional MRI, Würzburg , 2008.
Lars Matthäus, Peter Trillenberg, Tommaso Fadini, Markus Finke, and Achim Schweikard,
Brain mapping with Transcranial Magnetic Stimulation using a refined Correlation Ratio and Kendall's tau, Statistics in Medicine , vol. 27, no. 25, pp. 5252-5270, 2008.
DOI:10.1002/sim.3353
File: sim.3353
Lars Matthäus,
A robotic assistance system for transcranial magnetic stimulation and its application to motor cortex mapping, 2008.

2007

Markus Finke, Ralf Bruder, Lars Matthäus, and Achim Schweikard,
Spulenpositionierung bei TMS-Behandlungen mit Hilfe von Kraftsensorik, 2007.

2006

Lars Matthäus, Alf Giese, Daniel Wertheimer, and Achim Schweikard,
Solving the positioning problem in TMS, GMS CURAC , vol. 1, 2006.
Lars Matthäus, Alf Giese, Daniel Wertheimer, and Achim Schweikard,
Planning and analyzing robotized TMS using virtual reality., Studies in Health Technology and Informatics , vol. 119, pp. 373-378, 2006.
Lars Matthäus, Peter Trillenberg, Christoph Bodensteiner, Alf Giese, and Achim Schweikard,
Robotized TMS for motion compensated navigated brain stimulation, Osaka, Japan , 2006.

2005

Lars Matthäus, Alf Giese, Daniel Wertheimer, and Achim Schweikard,
Brainmapping With TMS Using A Robot Based Protocol And Image Registration Techniques, Berlin: VDI-Verlag, 2005. pp. 23.